Experimental and clinical nephroprotection by the xanthine oxidase inhibitor febuxostat
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چکیده
منابع مشابه
Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice
Atherosclerosis is a chronic inflammatory disease due to lipid deposition in the arterial wall. Multiple mechanisms participate in the inflammatory process, including oxidative stress. Xanthine oxidase (XO) is a major source of reactive oxygen species (ROS) and has been linked to the pathogenesis of atherosclerosis, but the underlying mechanisms remain unclear. Here, we show enhanced XO express...
متن کاملThe xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic
35 Xanthine oxidase (XO) is an enzyme involved in the production of uric acid (UA) 36 from purine nucleotides. Numerous recent studies have revealed the prevalence of 37 metabolic syndrome including non-alcoholic fatty liver disease (NAFLD) or 38 steatohepatitis (NASH) to be related to hyperuricemia. However, it remains unclear 39 whether elevated serum UA during the development of NAFLD or NAS...
متن کاملThe xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.
Xanthine oxidase (XO) is an enzyme involved in the production of uric acid (UA) from purine nucleotides. Numerous recent studies have revealed the likelihood of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH) to be related to hyperuricemia. However, it remains unclear whether elevated serum UA during the development of NAFLD or NASH is a cause or ...
متن کاملCharacterization and Thermodynamic Relationship of Three Polymorphs of a Xanthine Oxidase Inhibitor, Febuxostat.
Febuxostat (FXT), a xanthine oxidase inhibitor, is an interesting and unique molecule, which exhibits extensive polymorphism, with over 15 polymorphic forms reported to date. The primary purpose of the study was to characterize the three polymorphic forms with respect to their thermodynamic quantities and establish thermodynamic relationship between them. The polymorphs were characterized by th...
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ژورنال
عنوان ژورنال: Naunyn-Schmiedeberg's Archives of Pharmacology
سال: 2016
ISSN: 0028-1298,1432-1912
DOI: 10.1007/s00210-016-1260-4